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Clinithink Partners with Mount Sinai Health System to Transform Clinical Trials Recruitment

Posted by Clinithink on 21/06/2016


New York, NY (June 21, 2016) – Following a successful evaluation of CLiX accelerate at the Icahn School of Medicine at Mount Sinai (ISMMS), Mount Sinai has signed an agreement with the company to deploy the solution across the organisation to accelerate patient recruitment for clinical trials, as well as to support its personalised medicine initiatives.

CLiX accelerate will help to streamline the patient pre-screening process at Mount Sinai by processing large volumes of progress notes and reports from electronic health records and flagging patients whose clinical documentation indicates they closely match a trial’s inclusion/exclusion criteria. The result is a list, a prioritised shortlist of highly eligible patients. This will allow investigators to be much quicker in selecting patients to approach for consent and screening. The solution removes the need for extensive manual chart reviews almost entirely, releasing valuable time traditionally spent by site investigators and coordinators on this laborious task.

A multidisciplinary team of investigators from The Samuel F. Bronfman Department of Medicine, The Charles Bronfman Institute of Personalised Medicine and the Division of Nephrology at The Mount Sinai Hospital, recently worked with an expert Clinithink team to apply CLiX accelerate to an ongoing diabetic nephropathy trial and evaluate the results.

“Using CLiX accelerate, we did in a week what would have previously taken four months, so this could represent a paradigm shift in the way clinical trials are carried out for both common as well as rare diseases,” said Girish N. Nadkarni, MD, Clinical Instructor of Medicine/Nephrology at Mount Sinai and lead investigator for the CLiX accelerate evaluation.

Steven Coca, DO, Associate Professor of Medicine at Mount Sinai and executive sponsor of the evaluation added, “This technology allows us to speed up patient recruitment and find many more qualified candidates early in the process, allowing for shorter, more efficient trials and saving precious investigator and study coordinator time.”

In a second case study, the evaluation team retrospectively applied CLiX accelerate to a trial in a rare kidney disorder. The team found that CLiX accelerate would have increased trial enrollment by 250 percent and eligible patients were found in a fraction of the time.

“This technology is a game changer in the way we will find quality candidates for our clinical trials and will allow us to significantly increase the number of patients to whom we can offer participation in a clinical trial,” said Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean of the Icahn School of Medicine at Mount Sinai.  “This initiative is perfectly aligned with Mount Sinai’s vision and mission to drive innovation in healthcare to benefit our patients.”

“Clinical trial recruitment is becoming more and more difficult,” said Dr. Chris Tackaberry, MB, CEO of Clinithink.  “We believe that our CLiX accelerate solution addresses this problem in a highly innovative and very significant way. We are delighted to be collaborating with Mount Sinai to demonstrate this and show that clinical narrative data, a currently untapped asset, can be successfully exploited with our technology in ways not previously possible.”

About the Mount Sinai Health System

The Mount Sinai Health System is an integrated health system committed to providing distinguished care, conducting transformative research, and advancing biomedical education. Structured around seven hospital campuses and a single medical school, the Health System has an extensive ambulatory network and a range of inpatient and outpatient services—from community-based facilities to tertiary and quaternary care.

The System includes approximately 6,100 primary and specialty care physicians; 12 joint-venture ambulatory surgery centers; more than 140 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. Physicians are affiliated with the renowned Icahn School of Medicine at Mount Sinai, which is ranked among the highest in the nation in National Institutes of Health funding per investigator. The Mount Sinai Hospital is ranked as one of the nation’s top 10 hospitals in Geriatrics, Cardiology/Heart Surgery, and Gastroenterology, and is in the top 25 in five other specialties in the 2015-2016 “Best Hospitals” issue of U.S. News & World Report. Mount Sinai’s Kravis Children’s Hospital also is ranked in seven out of ten pediatric specialties by U.S. News & World Report. The New York Eye and Ear Infirmary of Mount Sinai is ranked 11th nationally for Ophthalmology, while Mount Sinai Beth Israel is ranked regionally.

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About Clinithink

Clinithink is the healthcare industry’s preferred text analytics provider, enabling innovative discoveries through the interrogation of unstructured data. CLiX accelerate automates the process of reviewing narrative written by clinicians, as well as various documents and reports. This is achieved by designing CLiX Queries, within an intuitive user interface, which match study inclusion and exclusion criteria. The CLiX natural language processing (NLP) engine allows it to “read” and encode millions of documents against these queries, thus producing a list of highly eligible and priority patients who match the study criteria.

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